My daughter’s Leapster2 stopped responding. Here is how I re-calibrated the tocuh-screen.

1.) Ensure that a cartridge is NOT inserted.
2.) Hold down the Hint (’?’) button while turning the unit on.
3.) When the LEAPSTER menu screen appears, press the ‘A’ button.
4.) Touch each of the crosshairs that appear with the stylus.
5.) Restart the unit.